Description

N,n-Dimethyldoxorubicin is a chemically modified derivative of the potent anthracycline antibiotic, doxorubicin. This compound is of significant interest for its potential to modulate the pharmacological profile, including activity and toxicity, of the parent drug. It is primarily utilized in advanced pharmaceutical research and development, particularly in the fields of oncology and medicinal chemistry. Researchers and manufacturers in the life sciences sector require this high-purity intermediate for synthesizing novel therapeutic agents and conducting structure-activity relationship (SAR) studies.

Application

• Pharmaceutical Intermediate: Key starting material or advanced intermediate in the synthesis of novel anthracycline-based chemotherapeutic agents.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new analogs with improved efficacy or reduced side effects.
• Oncology Drug Development: Serves as a critical reference standard and building block in preclinical research for new cancer therapies.
• Biochemical Research: Employed in studies investigating the mechanisms of action, resistance, and cellular uptake of anthracycline drugs.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control of related pharmaceutical products.

Basic Information

Product Name	N,n-Dimethyldoxorubicin
CAS No.	70222-95-6
Molecular Formula	C₂₉H₃₃NO₁₂
Molecular Weight	587.57 g/mol
Synonyms	N,N-Dimethyldoxorubicin; 14-O-[4-(Dimethylamino)butyryl]doxorubicin; AD 143; AD-143; AD143; FCE 23762; FCE-23762; N,N-Dimethyl-14-O-(4-aminobutyryl)doxorubicin
EINECS	Contact for details

Quality Control

Our N,n-Dimethyldoxorubicin is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR), and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with research-grade specifications. We support our clients' regulatory needs with full documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.