Description

9-Fluoro-11,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 21-Acetate is a high-purity synthetic corticosteroid derivative, a key intermediate in the synthesis of more complex and potent steroid-based pharmaceuticals. Its value lies in its precise molecular structure, which is critical for developing active pharmaceutical ingredients (APIs) with targeted anti-inflammatory and immunosuppressive properties. This compound is essential for pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of advanced steroid therapeutics.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the multi-step synthesis of potent topical and systemic corticosteroids.
• Research & Development: Serves as a reference standard and starting material in medicinal chemistry for developing new anti-inflammatory drugs.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the manufacture of steroid APIs where the 9-fluoro and 21-acetate modifications are required for enhanced biological activity and stability.
• Biochemical Research: Employed in studies investigating glucocorticoid receptor binding, metabolism, and structure-activity relationships (SAR) of steroid hormones.

Basic Information

Product Name	9-Fluoro-11,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 21-Acetate
CAS No.	7793-38-6
Molecular Formula	C23H29FO6
Molecular Weight	420.47 g/mol
Synonyms	9α-Fluoro-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate; 9α-Fluoroprednisolone 21-acetate; Fluorprednisolone acetate; 9-Fluoroprednisolone 21-acetate; NSC 47439; 1,4-Pregnadiene-9α-fluoro-11β,17α,21-triol-3,20-dione 21-acetate
EINECS	Contact for details

Quality Control

Our 9-Fluoro-11,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 21-Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.