Description

(E/Z)-Tamoxifen CAS NO 7728-73-6 is a non-steroidal selective estrogen receptor modulator (SERM) of significant pharmaceutical importance. This compound is a critical intermediate and reference standard in the research, development, and quality control of breast cancer therapeutics. It is essential for pharmaceutical manufacturers, analytical laboratories, and research institutions engaged in oncology drug development, bioequivalence studies, and impurity profiling.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of the active pharmaceutical ingredient (API) Tamoxifen Citrate.
• Reference Standard: Used as a certified reference material (CRM) for identity, assay, and impurity testing in pharmacopeial (USP, EP) quality control.
• Research & Development: Employed in preclinical and clinical studies to investigate the pharmacology, metabolism, and stability of SERM-based therapies.
• Impurity Profiling: Critical for identifying and quantifying the (E) and (Z) isomers and related substances in final drug product batches.
• Bioanalytical Studies: Utilized as a standard for method development and validation in LC-MS/MS and HPLC assays for pharmacokinetic studies.
• Academic Research: Applied in biochemical and molecular biology research to study estrogen receptor interactions and mechanisms of action.

Basic Information

Product Name	(E/Z)-Tamoxifen
CAS No.	7728-73-6
Molecular Formula	C26H29NO
Molecular Weight	371.52 g/mol
Synonyms	Tamoxifen Base; (Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine; trans-Tamoxifen; ICI 46474; Nolvadex Base; Kessar; Soltamox Base; Anti-estrogen
EINECS	231-775-7

Quality Control

Our (E/Z)-Tamoxifen is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including isomer-specific HPLC analysis, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) detailing all test results, which align with in-house specifications developed for pharmaceutical applications. Custom synthesis and purification to meet specific pharmacopeial or client requirements are available.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to prevent isomerization or degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (Total of E and Z isomers)
Isomer Ratio (Z/E)	Contact for details
Related Substances (HPLC)	Individual unknown impurity: ≤0.5% Total impurities: ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤20 ppm
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.