Description

Diphenhydramine Salicylate is a pharmaceutical-grade salt formed from the antihistamine diphenhydramine and salicylic acid. This compound is valued for its combined pharmacological properties, offering both antihistaminic and mild analgesic/anti-inflammatory effects. It is primarily utilized in the formulation of topical analgesic and antipruritic (anti-itch) medications for the pharmaceutical and over-the-counter (OTC) healthcare sectors.

Application

• Topical Analgesic Creams and Gels: A key active ingredient in formulations designed to relieve muscle aches, joint pain, and minor arthritis discomfort.
• Antipruritic Preparations: Used in creams, ointments, and sprays to alleviate itching associated with insect bites, minor skin irritations, rashes, and allergic reactions.
• Sports Medicine Products: Incorporated into topical solutions for athletes to manage pain and inflammation from minor strains and sprains.
• Veterinary Pharmaceuticals: Employed in topical treatments for skin conditions and localized pain relief in animals.
• Cosmaceutical Ingredients: Potential use in specialized skincare products targeting redness and irritation.

Basic Information

Product Name	Diphenhydramine Salicylate
CAS No.	7491-10-3
Molecular Formula	C24H27NO4
Molecular Weight	393.48 g/mol
Synonyms	2-(Diphenylmethoxy)-N,N-dimethylethylamine salicylate; Diphenhydramine 2-hydroxybenzoate; Benadryl Salicylate; Difenidramina Salicilato; Diphenhydramini Salicylas; DPS
EINECS	Contact for details

Quality Control

Our Diphenhydramine Salicylate is manufactured and tested to meet stringent pharmaceutical-grade standards. Quality assurance protocols include identity confirmation, purity assay, and control of specific impurities to ensure batch-to-batch consistency and efficacy for final formulations. A comprehensive Certificate of Analysis (COA) documenting all test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.