Description

4-Fluorocinnamonitrile is a versatile fluorinated aromatic nitrile building block essential for advanced organic synthesis. Its molecular structure, featuring both a fluorine substituent and a cyano group on a styrene backbone, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of fluorinated drug candidates, including kinase inhibitors and CNS-active compounds.
• Agrochemical Synthesis: Used to create novel fluorinated pesticides and herbicides, where the fluorine atom enhances biological activity and metabolic stability.
• Material Science Research: Acts as a monomer or building block for developing specialty polymers and liquid crystals with specific optical or electronic properties.
• Chemical Biology Probes: Employed in the design of fluorinated probes and tags for studying biological mechanisms and interactions.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed reactions, such as Suzuki-Miyaura couplings, to create biaryl structures.
• Fine Chemical Production: Integral to the multi-step synthesis of complex fluorinated fine chemicals and flavors/fragrances.

Basic Information

Product Name	4-Fluorocinnamonitrile
CAS No.	7182-77-6
Molecular Formula	C9H6FN
Molecular Weight	147.15 g/mol
Synonyms	(E)-3-(4-Fluorophenyl)acrylonitrile; 4-Fluorocinnameonitrile; trans-4-Fluorocinnamonitrile; (E)-3-(4-Fluorophenyl)-2-propenenitrile; 4-Fluorobenzylideneacetonitrile; p-Fluorocinnamonitrile; 4-Fluorostyryl cyanide; 4-Fluorophenylacrylonitrile
EINECS	Contact for details

Quality Control

Our 4-Fluorocinnamonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	85 - 89 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.