Description

1-Bromo-3-Fluoro-5-Nitrobenzene is a high-purity halogenated nitrobenzene derivative serving as a critical building block in advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and nitro substituents, makes it an indispensable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system and anti-inflammatory pathways.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, where the fluorine atom enhances biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Manufacturing: Acts as an intermediate for synthesizing complex, high-performance dyes and pigments.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Nucleophilic Aromatic Substitution: The presence of nitro and fluoro groups activates the molecule for selective substitution reactions.

Basic Information

Product Name	1-Bromo-3-Fluoro-5-Nitrobenzene
CAS No.	7087-65-2
Molecular Formula	C6H3BrFNO2
Molecular Weight	220.00 g/mol
Synonyms	3-Bromo-5-fluoronitrobenzene; 5-Bromo-3-fluoronitrobenzene; 1-Fluoro-3-bromo-5-nitrobenzene; 3-Fluoro-5-bromonitrobenzene; 5-Fluoro-3-bromonitrobenzene; Benzene, 1-bromo-3-fluoro-5-nitro-; NSC 403120
EINECS	Contact for details

Quality Control

Our 1-Bromo-3-Fluoro-5-Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in dark conditions.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.