Description

2-Chloro-4,5-Difluoronitrobenzene is a high-purity, multi-functional aromatic intermediate of significant importance in advanced organic synthesis. Its unique halogenated and nitrated structure makes it a critical building block for constructing complex molecules with tailored properties. This compound is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing difluorophenyl or chloronitrobenzene motifs.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and pesticides, where the fluorine and chlorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorine-containing aromatic compounds used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modifiers: Incorporated into specialty polymers to impart specific chemical resistance, thermal stability, or surface properties.
• Dye & Pigment Intermediate: Utilized in the production of complex, high-performance dyes and pigments for industrial applications.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create biaryl structures.
• Nucleophilic Aromatic Substitution: The activated nitro and halogen groups make it reactive in SNAr reactions for introducing various nucleophiles.
• Research & Development: A valuable reagent for academic and industrial R&D in medicinal chemistry and material science.

Basic Information

Item	Details
Product Name	2-Chloro-4,5-Difluoronitrobenzene
CAS No.	771-76-6
Molecular Formula	C6H2ClF2NO2
Molecular Weight	193.54 g/mol
Synonyms	1-Chloro-2,3-difluoro-4-nitrobenzene; Benzene, 2-chloro-1,4-difluoro-5-nitro-; 2,3-Difluoro-4-nitrochlorobenzene; 4-Nitro-2,3-difluorochlorobenzene; 2-Chloro-1,4-difluoro-5-nitrobenzene; 5-Nitro-2,3-difluorochlorobenzene; 2,3-Difluoro-6-nitrochlorobenzene (ambiguous); 771-76-6 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our 2-Chloro-4,5-Difluoronitrobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistent lot-to-lot performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in dark conditions. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.