Description

4-(Trifluoromethoxy)Nitrobenzene is a versatile fluorinated aromatic intermediate of significant importance in advanced organic synthesis. Its unique structure, featuring both a nitro group and a trifluoromethoxy substituent, makes it a critical building block for introducing specific functionalities into target molecules. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a trifluoromethoxy-phenyl moiety.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the nitro group serves as a handle for further chemical transformation.
• Liquid Crystal & OLED Materials: Serves as a starting material for synthesizing fluorinated components used in electronic display technologies.
• Functional Dye & Pigment Intermediate: Employed in the creation of specialized dyes and pigments with enhanced properties.
• Cross-Coupling Reactions: The nitro group can be reduced to an amine, making it a valuable substrate for Buchwald-Hartwig amination and other palladium-catalyzed couplings.
• Organic Synthesis Research: A valuable reagent for academic and industrial R&D exploring new fluorination methodologies and aromatic substitution reactions.

Basic Information

Product Name	4-(Trifluoromethoxy)Nitrobenzene
CAS No.	713-65-5
Molecular Formula	C7H4F3NO3
Molecular Weight	207.11 g/mol
Synonyms	1-Nitro-4-(trifluoromethoxy)benzene; p-(Trifluoromethoxy)nitrobenzene; 4-Nitro-α,α,α-trifluoroanisole; α,α,α-Trifluoro-p-nitroanisole; Nitrophenyl trifluoromethyl ether; 4-Trifluoromethoxynitrobenzene; 4-Nitrophenyl trifluoromethyl ether
EINECS	211-933-6

Quality Control

Our 4-(Trifluoromethoxy)Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	34 - 38 °C
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.