Description

1-Fluoro-2-Methoxy-5-Methyl-3-Nitrobenzene is a high-purity, multi-functional aromatic intermediate featuring distinct fluorine, methoxy, methyl, and nitro substituents. This compound is valued for its role as a versatile building block in advanced organic synthesis, enabling the introduction of specific functional groups into complex molecular architectures. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a fluorinated aromatic core for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the fluorine atom and nitro group are critical for biological activity.
• Liquid Crystal & OLED Material Research: Serves as a building block for creating novel fluorinated aromatic compounds used in electronic display technologies.
• Dye & Pigment Intermediate: Employed in the synthesis of specialized dyes and pigments, leveraging the nitro and methoxy groups for color development and stability.
• Cross-Coupling Reactions: An effective substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for constructing complex biaryl structures.
• Academic & Contract Research: A valuable reagent for methodological development and exploratory research in academic laboratories and CROs (Contract Research Organizations).

Basic Information

Item	Details
Product Name	1-Fluoro-2-Methoxy-5-Methyl-3-Nitrobenzene
CAS No.	708-04-3
Molecular Formula	C8H8FNO3
Molecular Weight	185.15 g/mol
Synonyms	2-Fluoro-6-Methoxy-4-Nitrotoluene; 3-Nitro-2-Fluoro-6-Methoxytoluene; 2-Fluoro-6-methoxy-4-methyl-1-nitrobenzene; 4-Methyl-2-fluoro-6-methoxynitrobenzene; 1-Fluoro-2-methoxy-5-methyl-3-nitro-benzene; 708-04-3; 2-Fluoro-6-methoxy-4-nitrotoluene
EINECS	Contact for details

Quality Control

Our 1-Fluoro-2-Methoxy-5-Methyl-3-Nitrobenzene is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and structural identity. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP and ISO 9001 standards for traceability and consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.