Description

Pregn-4-Ene-3,11,20-Trione, 9-Fluoro-17,21-Dihydroxy- is a synthetic corticosteroid intermediate of significant pharmaceutical importance. This compound serves as a critical building block in the synthesis of potent anti-inflammatory and immunosuppressive steroid drugs. It is primarily required by pharmaceutical R&D laboratories and active pharmaceutical ingredient (API) manufacturers for the production of advanced corticosteroid therapeutics.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of fluorinated corticosteroid APIs such as dexamethasone, betamethasone, and related analogues.
• Anti-inflammatory Drug Research: Used in medicinal chemistry for developing new glucocorticoid receptor agonists with improved potency and selectivity.
• Process Chemistry & Scale-up: Employed in optimizing synthetic routes for the commercial manufacturing of steroid-based medicines.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical production.
• Biochemical Research: Utilized in studies investigating steroid hormone action, metabolism, and receptor binding mechanisms.

Basic Information

Product Name	Pregn-4-Ene-3,11,20-Trione, 9-Fluoro-17,21-Dihydroxy-
CAS No.	79-60-7
Molecular Formula	C21H27FO5
Molecular Weight	378.44 g/mol
Synonyms	9-Fluoro-11β,17α,21-trihydroxypregn-4-ene-3,20-dione; 9α-Fluoro-11β,17α,21-trihydroxypregn-4-ene-3,20-dione; 9-Fluoro-11β,17,21-trihydroxypregn-4-ene-3,20-dione; 9α-Fluoroprednisolone; Fluorprednisolone; NSC 47439; 9-Fluoro-17,21-dihydroxypregn-4-ene-3,11,20-trione
EINECS	201-211-8

Quality Control

Our Pregn-4-Ene-3,11,20-Trione, 9-Fluoro-17,21-Dihydroxy- is produced under strict quality management systems. We offer material suitable for pharmaceutical R&D and synthesis, with typical purity grades exceeding 98% (HPLC). Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each batch to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.