Description

4-(1,4-Dioxa-8-Aza-Spiro[4.5]Dec-8-Yl)-1,1,1-Trifluoro-Butan-2-Ol is a sophisticated trifluoromethylated spirocyclic amino alcohol building block of significant interest in advanced organic synthesis. This compound matters because its unique structure, featuring a protected amino group and a fluorinated alcohol moiety, enables the efficient construction of complex molecules with tailored properties. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients, as well as by manufacturers of specialty materials and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, particularly those targeting the central nervous system (CNS) and metabolic diseases.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, where the trifluoromethyl group can enhance biological activity and environmental stability.
• Ligand Synthesis: Serves as a precursor for chiral ligands and catalysts used in asymmetric synthesis, crucial for producing enantiomerically pure compounds.
• Fluorinated Material Precursor: Incorporated into the synthesis of specialty polymers, liquid crystals, or surface-active agents where fluorine atoms impart unique chemical resistance and surface properties.
• Chemical Biology Probe Development: Utilized to create molecular probes and tool compounds for studying biological pathways and protein interactions.
• Peptidomimetic Chemistry: The spirocyclic and amino alcohol structure makes it valuable for constructing conformationally constrained peptide analogs.

Basic Information

Item	Detail
Product Name	4-(1,4-Dioxa-8-Aza-Spiro[4.5]Dec-8-Yl)-1,1,1-Trifluoro-Butan-2-Ol
CAS No.	692737-14-7
Molecular Formula	C12H18F3NO3
Molecular Weight	281.27 g/mol
Synonyms	1,1,1-Trifluoro-4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)butan-2-ol; 4-(1,4-Dioxa-8-azaspiro[4.5]decan-8-yl)-1,1,1-trifluorobutan-2-ol; 8-[3-(Trifluoromethyl)-3-hydroxypropyl]-1,4-dioxa-8-azaspiro[4.5]decane; Trifluoromethyl Spirocyclic Amino Alcohol; 4-(1,4-Dioxa-8-aza-spiro[4.5]dec-8-yl)-1,1,1-trifluoro-butan-2-ol; 692737-14-7; 4-(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)-1,1,1-trifluoro-2-butanol
EINECS	Contact for details

Quality Control

Our 4-(1,4-Dioxa-8-Aza-Spiro[4.5]Dec-8-Yl)-1,1,1-Trifluoro-Butan-2-Ol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.