Description

6,8-Difluoro-Chroman-3-Ylamine Hydrochloride is a high-purity fluorinated chroman derivative, serving as a critical chiral building block and intermediate in advanced organic synthesis. Its value lies in providing a structurally defined, functionalized scaffold essential for constructing complex molecules with potential biological activity. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the discovery and process development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel therapeutic agents, particularly in central nervous system (CNS) and cardiovascular drug discovery programs.
• Agrochemical Synthesis: Used in the development of new generation pesticides and herbicides, where the difluoro-chroman core can contribute to enhanced activity and metabolic stability.
• Chemical Biology Probe Development: Serves as a precursor for fluorescent tags or molecular probes to study enzyme mechanisms and biological pathways.
• Asymmetric Catalysis Research: Employed as a substrate or ligand precursor in the development of new catalytic systems for enantioselective synthesis.
• Material Science Research: Potential building block for novel organic electronic materials or liquid crystals due to its rigid, fluorinated aromatic structure.

Basic Information

Product Name	6,8-Difluoro-Chroman-3-Ylamine Hydrochloride
CAS No.	677773-53-4
Molecular Formula	C9H8F2NO.ClH
Molecular Weight	221.62 g/mol (Free base: 185.16 g/mol)
Synonyms	3-Amino-6,8-difluorochroman hydrochloride; 6,8-Difluoro-3-chromanamine hydrochloride; 6,8-Difluorochroman-3-amine HCl; 2,3-Dihydro-6,8-difluoro-2H-1-benzopyran-3-amine hydrochloride; (3R/S)-6,8-Difluorochroman-3-amine hydrochloride; 677773-53-4; Chroman-3-amine, 6,8-difluoro-, hydrochloride
EINECS	Contact for details

Quality Control

Our 6,8-Difluoro-Chroman-3-Ylamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to ensure full traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed after each use to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.