Description

1-Bromo-5-Fluoro-4-Methoxy-2-Nitrobenzene is a high-purity, multi-functional halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique substitution pattern makes it a critical intermediate for constructing complex molecular architectures, particularly in the pharmaceutical and agrochemical sectors. This compound is primarily sought after by R&D chemists and process development scientists for the synthesis of active pharmaceutical ingredients (APIs), functional materials, and specialized fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging the fluorine and nitro groups for bioactivity.
• Material Science Research: Serves as a building block for creating specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing substituents.
• Dye and Pigment Manufacturing: Acts as an intermediate in the production of complex, high-performance dyes and pigments.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Heck, and Buchwald-Hartwig aminations.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for biochemical research and diagnostic applications.

Basic Information

Product Name	1-Bromo-5-Fluoro-4-Methoxy-2-Nitrobenzene
CAS No.	661463-13-4
Molecular Formula	C7H5BrFNO3
Molecular Weight	250.02 g/mol
Synonyms	2-Bromo-4-Fluoro-5-Methoxy-1-Nitrobenzene; 4-Bromo-2-Fluoro-5-Methoxynitrobenzene; 5-Bromo-2-Fluoro-4-Methoxynitrobenzene; Benzene, 1-bromo-5-fluoro-4-methoxy-2-nitro-; 1-Bromo-5-fluoro-4-methoxy-2-nitrobenzene; 661463-13-4
EINECS	Contact for details

Quality Control

Our 1-Bromo-5-Fluoro-4-Methoxy-2-Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be stored away from light.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.