Description

2-Fluoro-6-Piperidinobenzonitrile is a high-value, fluorinated aromatic nitrile building block featuring a piperidine substituent. This compound is critical for medicinal chemistry research and pharmaceutical development, offering a versatile scaffold for creating novel bioactive molecules. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, particularly kinase inhibitors and central nervous system (CNS) active compounds.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies and lead optimization due to its fluorine atom and piperidine moiety.
• Agrochemical Synthesis: Serves as a precursor in the development of new pesticides and herbicides, leveraging the biological activity of the fluorobenzonitrile core.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specialized fluorinated intermediates.
• Academic Research: Employed in university and institutional labs for exploratory organic synthesis and the development of new catalytic methodologies.

Basic Information

Product Name	2-Fluoro-6-Piperidinobenzonitrile
CAS No.	646989-68-6
Molecular Formula	C₁₂H₁₃FN₂
Molecular Weight	204.24 g/mol
Synonyms	6-Piperidino-2-fluorobenzonitrile; 2-Fluoro-6-(piperidin-1-yl)benzonitrile; 2-Fluoro-6-(1-piperidinyl)benzonitrile; 2-Fluoro-6-piperidin-1-yl-benzonitrile; Benzonitrile, 2-fluoro-6-(1-piperidinyl)-; 1-(2-Cyano-3-fluorophenyl)piperidine; 646989-68-6 (CAS)
EINECS	Contact for details

Quality Control

Our 2-Fluoro-6-Piperidinobenzonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability, consistency, and reliability for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.