Description

1-Chloro-5-Methoxy-4-Nitro-2-(Trifluoromethyl)Benzene is a high-value, multi-functional aromatic intermediate characterized by its distinct trifluoromethyl and nitro substituents. This compound is essential for the synthesis of advanced molecules, offering significant advantages in tuning the physicochemical properties of target compounds, such as enhanced metabolic stability and lipophilicity. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group contributes to biological activity and environmental stability.
• Material Science Research: Serves as a precursor for developing specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing groups.
• Dye and Pigment Intermediate: Employed in the synthesis of complex, high-performance dyes and pigments for specialized industrial applications.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for constructing complex biaryl structures.

Basic Information

Product Name	1-Chloro-5-Methoxy-4-Nitro-2-(Trifluoromethyl)Benzene
CAS No.	646989-36-8
Molecular Formula	C8H5ClF3NO3
Molecular Weight	255.58 g/mol
Synonyms	2-Chloro-5-methoxy-4-nitrobenzotrifluoride; 5-Methoxy-4-nitro-2-(trifluoromethyl)chlorobenzene; 1-Chloro-2-(trifluoromethyl)-5-methoxy-4-nitrobenzene; 2-Chloro-α,α,α-trifluoro-5-methoxy-4-nitrotoluene; 4-Nitro-5-methoxy-2-(trifluoromethyl)chlorobenzene; 646989-36-8; Benzene, 1-chloro-5-methoxy-4-nitro-2-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 1-Chloro-5-Methoxy-4-Nitro-2-(Trifluoromethyl)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.