Description

3-(Trifluoromethyl)Pyrrolidine is a versatile fluorinated heterocyclic building block essential for modern synthetic chemistry. Its unique structure, featuring a pyrrolidine ring substituted with a strongly electron-withdrawing trifluoromethyl group, makes it a critical intermediate for introducing lipophilicity and metabolic stability into target molecules. This high-value compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of drug candidates, particularly in central nervous system (CNS) and oncology research, where the trifluoromethyl group enhances bioavailability and binding affinity.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging the fluorine moiety to improve pesticidal activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis, enabling the production of enantiomerically pure compounds.
• Material Science Research: Incorporated into novel polymers and advanced materials to modify surface properties, thermal stability, and chemical resistance.
• Fluorine Chemistry & SAR Studies: An indispensable tool for structure-activity relationship (SAR) studies in medicinal chemistry to explore the effects of fluorination.

Basic Information

Product Name	3-(Trifluoromethyl)Pyrrolidine
CAS No.	644970-41-2
Molecular Formula	C5H8F3N
Molecular Weight	139.12 g/mol
Synonyms	3-(Trifluoromethyl)pyrrolidine; Pyrrolidine, 3-(trifluoromethyl)-; 3-Trifluoromethylpyrrolidine; 3-(Trifluoromethyl)-1-azacyclopentane; 1-Azabicyclo[3.1.0]hexane, 3-(trifluoromethyl)- (related bicyclic form); α-(Trifluoromethyl)pyrrolidine; TFMP
EINECS	Contact for details

Quality Control

We supply 3-(Trifluoromethyl)Pyrrolidine in high-purity grades suitable for research and commercial synthesis. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles by GC/HPLC are available upon request. We adhere to a cGMP-compliant quality management system to ensure batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use. Keep away from strong bases and oxidizing agents. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.