Description

4-(Aminomethyl)-3,5-Difluorobenzonitrile is a versatile aromatic nitrile building block featuring both an aminomethyl group and fluorine substituents. This unique bifunctional structure makes it a critical intermediate for synthesizing advanced pharmaceutical compounds and high-performance agrochemicals. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules with tailored biological activity.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors, central nervous system (CNS) agents, and anti-cancer drugs.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides, where the fluorine atoms enhance metabolic stability and bioavailability.
• Ligand & Catalyst Development: Used to create novel chelating ligands for transition metal catalysts in asymmetric synthesis and cross-coupling reactions.
• Material Science Monomer: Serves as a functional monomer for developing specialty polymers, such as polyamides or polyimides, with unique thermal and chemical resistance properties.
• Fluorinated Compound Library: Essential scaffold for medicinal chemistry and combinatorial chemistry to build diverse libraries of fluorinated compounds for high-throughput screening.
• Peptidomimetic Research: The aminomethyl group allows for incorporation into peptide backbones to create stable, fluorinated peptidomimetics.

Basic Information

Product Name	4-(Aminomethyl)-3,5-Difluorobenzonitrile
CAS No.	633336-81-9
Molecular Formula	C8H6F2N2
Molecular Weight	168.15 g/mol
Synonyms	3,5-Difluoro-4-(aminomethyl)benzonitrile; 4-(Aminomethyl)-3,5-difluorobenzonitrile; 3,5-Difluoro-4-cyanobenzylamine; Benzonitrile, 4-(aminomethyl)-3,5-difluoro-; 4-Cyano-2,6-difluorobenzylamine
EINECS	Contact for details

Quality Control

Our 4-(Aminomethyl)-3,5-Difluorobenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere such as nitrogen for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.