Description

2,4-Difluoro-5-Formylbenzonitrile is a high-value, multi-functional aromatic building block featuring both a formyl and a nitrile group on a difluorinated benzene ring. This unique structure makes it a critical intermediate for synthesizing complex molecules in advanced research and development. It is primarily sought after by pharmaceutical and agrochemical R&D teams for the construction of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and other small-molecule drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging the bioactivity of the difluoro and nitrile motifs.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Building block for novel organic electronic materials, liquid crystals, and polymers where fluorine substitution tunes electronic properties and stability.
• Custom Synthesis and Contract Manufacturing: Supplied to CROs and CDMOs for custom synthesis projects requiring precise, high-purity fluorinated intermediates.

Basic Information

Product Name	2,4-Difluoro-5-Formylbenzonitrile
CAS No.	633327-10-3
Molecular Formula	C8H3F2NO
Molecular Weight	167.11 g/mol
Synonyms	5-Cyano-2,4-difluorobenzaldehyde; 2,4-Difluorobenzaldehyde-5-carbonitrile; 2,4-Difluoro-5-formylbenzonitrile; 5-Formyl-2,4-difluorobenzonitrile; Benzonitrile, 2,4-difluoro-5-formyl-; 633327-10-3; 5-Cyano-2,4-difluorobenzenecarboxaldehyde
EINECS	Contact for details

Quality Control

Every batch of 2,4-Difluoro-5-Formylbenzonitrile is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure traceability and consistency for your critical R&D and production processes. A detailed Certificate of Analysis (COA) specifying purity, identity, and impurity profiles by HPLC, GC, and NMR is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound may be light-sensitive and should be handled under an inert atmosphere for long-term storage to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.