Description

3-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile is a high-value, synthetically versatile organoboron building block. Its core value lies in enabling efficient carbon-carbon and carbon-heteroatom bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone of modern pharmaceutical and advanced materials synthesis. This compound is essential for researchers and process chemists in pharmaceutical R&D, agrochemical discovery, and the development of organic electronic materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing fluorinated bioactive molecules, active pharmaceutical ingredients (APIs), and drug candidates.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides with enhanced properties.
• Material Science: Enables the creation of complex organic molecules for organic light-emitting diodes (OLEDs), semiconductors, and liquid crystals.
• Chemical Research & Development: A critical reagent for medicinal chemistry, facilitating rapid structure-activity relationship (SAR) studies and library synthesis.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura cross-coupling to introduce the 2-cyano-6-fluorophenyl moiety into target molecules.
• Fluorine Chemistry: Serves as a valuable synthon for incorporating both fluorine and boronic ester functional groups into complex architectures.

Basic Information

Item	Details
Product Name	3-Fluoro-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile
CAS No.	624741-47-5
Molecular Formula	C₁₃H₁₅BFNO₂
Molecular Weight	247.08 g/mol
Synonyms	2-Cyano-6-fluorophenylboronic acid pinacol ester; (2-Cyano-6-fluorophenyl)boronic acid pinacol ester; 3-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile; 2-Fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile; Benzonitrile, 3-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; Pinacol (2-cyano-6-fluorophenyl)boronate
EINECS	Contact for details

Quality Control

Our 3-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.