Description

Carvedilol Phosphate CAS NO 610309-89-2 is the phosphate salt form of the widely used non-selective β-blocker, carvedilol. This specific salt form is critical for enhancing the stability, solubility, and bioavailability of the active pharmaceutical ingredient (API) in finished drug formulations. It is an essential intermediate and raw material for pharmaceutical manufacturers developing and producing cardiovascular medications. The compound is primarily utilized in the synthesis of final dosage forms designed for the management of hypertension and heart failure.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Serves as the key chemical entity in the manufacture of finished carvedilol-based drug products.
• Cardiovascular Drug Formulation: Used in the development and production of tablets, capsules, and other oral dosage forms for treating hypertension (high blood pressure).
• Heart Failure Medication Production: A critical component in medications prescribed for chronic heart failure to improve survival and reduce hospitalization.
• Pharmaceutical Research & Development (R&D): Employed in preclinical and clinical studies for developing new therapeutic formulations or generic versions.
• Reference Standard: Can be used as a high-purity standard in analytical laboratories for quality control and method validation.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for commercial-scale pharmaceutical production.

Basic Information

Product Name	Carvedilol Phosphate
CAS No.	610309-89-2
Molecular Formula	C24H26N2O4 • H3PO4
Molecular Weight	513.46 g/mol (free base: 406.47)
Synonyms	Carvedilol phosphate salt; 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol phosphate; (±)-1-(Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol phosphate; BM-14190 phosphate; SKF-105517 phosphate; Coreg CR® (brand name formulation) active component; (RS)-1-(Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol phosphate
EINECS	Contact for details

Quality Control

Our Carvedilol Phosphate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for pharmaceutical use, including identity, purity, and impurity profiles. We provide full traceability and support regulatory submissions. Certificates of Analysis (COA) documenting compliance with relevant pharmacopeial standards (such as USP/EP) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.