Description

Timolol is a potent, non-selective β-adrenergic receptor antagonist widely recognized for its therapeutic efficacy. This compound is of critical importance in the pharmaceutical industry for its primary role in managing cardiovascular and ophthalmic conditions. It is an essential active pharmaceutical ingredient (API) for manufacturers developing medications to treat hypertension, angina, and, most notably, glaucoma. Global suppliers and pharmaceutical formulators require a reliable source of high-purity Timolol to ensure the safety and efficacy of their final drug products.

Application

• Ophthalmic Solutions: Primary API in eye drops for the reduction of intraocular pressure in the treatment of open-angle glaucoma and ocular hypertension.
• Cardiovascular Pharmaceuticals: Key ingredient in oral tablets and capsules for managing hypertension (high blood pressure) and angina pectoris.
• Migraine Prophylaxis: Used in formulations aimed at preventing migraine headaches.
• Myocardial Infarction Management: Component in post-heart attack (myocardial infarction) treatment regimens to improve survival rates.
• Pharmaceutical Intermediates: Serves as a crucial chemical intermediate in the synthesis of more complex drug molecules and salt forms (e.g., Timolol Maleate).
• Research & Development: Used in biochemical research as a standard and tool compound for studying β-adrenergic receptor pathways.

Basic Information

Product Name	Timolol
CAS No.	610271-57-3
Molecular Formula	C13H24N4O3S
Molecular Weight	316.42 g/mol
Synonyms	(S)-Timolol; (-)-Timolol; (S)-1-(tert-Butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-2-propanol; Timolol Base; Timolol Free Base; BLOCADREN; Timoptol; MK-950
EINECS	Contact for details

Quality Control

Our Timolol is manufactured under strict quality management systems to meet the exacting standards of the global pharmaceutical industry. Each batch is subjected to comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via advanced techniques like HPLC and GC. We provide full traceability and support regulatory submissions with comprehensive documentation. Certificates of Analysis (COA) are available upon request, detailing compliance with relevant pharmacopeial standards such as USP and EP.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Optical Rotation	-11.5° to -13.5° (c=1 in methanol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.