Description

9,10-Anhydrodaunorubicin is a key synthetic intermediate and derivative of the anthracycline antibiotic daunorubicin. This compound is of significant value in pharmaceutical research and development, particularly for the synthesis of novel chemotherapeutic agents. It is primarily utilized by research institutions, pharmaceutical manufacturers, and biotechnology companies engaged in oncology drug discovery and the development of advanced anti-cancer therapies.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel daunorubicin analogs and other anthracycline-based chemotherapeutic agents.
• Oncology Research: Used in biochemical and pharmacological studies to investigate structure-activity relationships (SAR) and mechanisms of action of anthracycline drugs.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical manufacturing and regulatory testing.
• Drug Discovery: Employed in medicinal chemistry programs aimed at developing new anti-cancer compounds with potentially improved efficacy or reduced side effects.
• Academic Research: Utilized in university and institutional labs for fundamental studies on DNA intercalation, topoisomerase inhibition, and cellular apoptosis pathways.
• Bioconjugate Development: Investigated as a potential payload for antibody-drug conjugates (ADCs) and other targeted drug delivery systems.

Basic Information

Product Name	9,10-Anhydrodaunorubicin
CAS No.	69804-36-0
Molecular Formula	C27H29NO9
Molecular Weight	511.52 g/mol
Synonyms	9,10-Anhydrodaunomycin; 9,10-Anhydro-13-dihydrodaunorubicin; 9,10-Anhydrodaunorubicinol; (7S,9S)-9-Acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-8,10-dihydro-7H-tetracene-5,12-dione; Daunorubicin, 9,10-anhydro-
EINECS	Contact for details

Quality Control

Our 9,10-Anhydrodaunorubicin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR, MS), and residual solvent analysis to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	Red to orange-red powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.