Description

Ansamitocins are a class of potent ansamycin antibiotics with significant antitumor activity, primarily known for their role as payloads in antibody-drug conjugates (ADCs). This compound matters for its high cytotoxicity and specificity, making it a critical component in targeted cancer therapies. It is essential for pharmaceutical R&D, oncology research, and the development of next-generation bioconjugates for treating various cancers.

Application

• Primary payload in the construction of antibody-drug conjugates (ADCs) for targeted cancer therapy.
• Key intermediate in the synthesis and research of novel antineoplastic agents and chemotherapeutic drugs.
• Reference standard for analytical method development and quality control in pharmaceutical manufacturing.
• Biochemical research tool for studying tubulin polymerization inhibition and mechanisms of apoptosis.
• Starting material for the derivatization and optimization of maytansinoid-based therapeutics.

Basic Information

Product Name	Ansamitocins
CAS No.	69279-90-9
Molecular Formula	C32H43ClN2O9
Molecular Weight	635.15 g/mol
Synonyms	Ansamitocin P-3; Antibiotic C 15003P3; Maytansinol, 4,5-deoxy-4,5-didehydro-19-demethoxy-19-oxo-3-(3-pyridinylcarbonyloxy)-, (3R,4S,5S,6R)-6-[[(2R,3R,4S,6S)-4-(dimethylamino)-6-methyl-2-oxo-3-tetrahydro-2H-pyranyl]oxy]methyl]-4-methoxy-5-methyl-3-(1-oxopropoxy)-2-tetrahydro-2H-pyranyl ester, (2R)-2-methylbutanoate; DM1; Mertansine; NSC 292222
EINECS	Contact for details

Quality Control

Our Ansamitocins are produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure compliance with research and pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and residual solvents is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.