Description

Astemizole is a high-purity, selective, long-acting histamine H1-receptor antagonist. This compound is of significant interest in pharmaceutical research and development due to its specific pharmacological profile. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents and the study of allergic response mechanisms.

Application

• Pharmaceutical Reference Standard: Serves as a critical quality control component for analytical testing and method validation in drug development and manufacturing.
• Active Pharmaceutical Ingredient (API) Intermediate: Used in the synthesis and research of novel antihistamine compounds and related drug candidates.
• Biochemical Research: Employed in in vitro and in vivo studies to investigate histamine receptor binding, allergic pathways, and cellular signaling mechanisms.
• Metabolite Studies: Acts as a precursor or standard for the analysis of metabolic pathways and pharmacokinetic profiling.
• Academic & Institutional Research: A key reagent for universities and research labs focusing on immunology, pharmacology, and medicinal chemistry.

Basic Information

Product Name	Astemizole
CAS No.	68844-77-9
Molecular Formula	C28H31FN4O
Molecular Weight	458.57 g/mol
Synonyms	1-[(4-Fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine; (±)-Astemizole; R 43512; Almizol; Hismanal; Paralergin; Simprox; Stemiz; 1-(p-Fluorobenzyl)-2-[[1-(2-p-methoxyphenylethyl)piperid-4-yl]amino]benzimidazole
EINECS	Contact for details

Quality Control

Our Astemizole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via HPLC and other validated methods, to ensure it meets the stringent requirements for research and development use. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.