Description

4-Hydroxybunitrolol is a key pharmaceutical intermediate and reference standard, primarily recognized for its role in the synthesis and analytical profiling of β-adrenergic blocking agents. Its importance lies in providing a critical building block for cardiovascular drug research and development, ensuring precise chemical pathways and quality control. This compound is essential for pharmaceutical manufacturers, R&D laboratories, and analytical service providers focused on developing and validating new therapeutic agents or generic formulations.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of β-blocker active pharmaceutical ingredients (APIs) and related analogs.
• Reference Standard: Used for analytical method development, validation, and quality control (QC) testing in pharmaceutical laboratories.
• Metabolite Studies: Serves as a reference compound for the identification and quantification of drug metabolites in pharmacokinetic and bioanalytical research.
• Chemical Research: Employed in academic and industrial R&D for exploring structure-activity relationships (SAR) of adrenergic receptor ligands.
• Impurity Profiling: Acts as a known impurity or degradation product standard to ensure the purity and stability of final drug products.

Basic Information

Product Name	4-Hydroxybunitrolol
CAS No.	68808-74-2
Molecular Formula	C17H20N2O3
Molecular Weight	300.36 g/mol
Synonyms	4-Hydroxybunitrolol; 1-(tert-Butylamino)-3-[(4-hydroxy-2,3,6-trimethylphenoxy)]-2-propanol; Bunitrolol, 4-hydroxy-; 4-Hydroxy-1-(tert-butylamino)-3-[(2,3,6-trimethyl-4-hydroxyphenoxy)]-2-propanol; 4'-Hydroxybunitrolol; 4-OH-Bunitrolol
EINECS	Contact for details

Quality Control

Our 4-Hydroxybunitrolol is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency suitable for pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can support development projects requiring specific analytical data packages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.