Description

6Alpha,9-Difluoro-11Beta,17,21-Trihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-Salicylate is a high-purity synthetic corticosteroid derivative, specifically the 21-salicylate ester of a difluorinated glucocorticoid. This compound is of significant value as a key pharmaceutical intermediate in the synthesis of potent topical anti-inflammatory and anti-pruritic medications. It is primarily required by manufacturers in the pharmaceutical and fine chemical sectors for the development of advanced dermatological treatments.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of high-potency topical corticosteroids.
• Active Pharmaceutical Ingredient (API) Manufacturing: Used in the production of final drug substances for dermatological creams and ointments.
• Anti-inflammatory Drug Research: Serves as a reference standard and starting material in R&D for new glucocorticoid receptor agonists.
• Veterinary Medicine: Potential use in formulating anti-inflammatory treatments for animal healthcare.
• Biochemical Research: Tool compound for studying steroid hormone action and receptor binding assays.

Basic Information

Item	Detail
Product Name	6Alpha,9-Difluoro-11Beta,17,21-Trihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-Salicylate
CAS No.	68497-94-9
Molecular Formula	C29H34F2O7
Molecular Weight	532.58 g/mol
Synonyms	Diflorasone Diacetate Related Compound; Diflorasone 21-Salicylate; 6α,9α-Difluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-salicylate; 16α-Methyl-6α,9α-difluoroprednisolone 21-salicylate; Salicylate ester of 6α,9α-difluoro-16α-methylprednisolone; NSC 134455; Diflorasone Impurity (Salicylate Ester)
EINECS	Contact for details

Quality Control

Our 6Alpha,9-Difluoro-11Beta,17,21-Trihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-Salicylate is manufactured under strict quality systems. Every batch is tested to ensure high chemical purity and identity, meeting the stringent requirements for pharmaceutical intermediate use. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and residual solvents is provided with each shipment to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.