Description

9-Fluoro-11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 21-Salicylate is a high-purity synthetic corticosteroid derivative, specifically a salicylate ester of a fluorinated pregnadiene. This compound is a critical advanced pharmaceutical intermediate valued for its potent anti-inflammatory and immunosuppressive activity. It is primarily utilized by research institutions and pharmaceutical manufacturers in the development and production of next-generation topical and systemic corticosteroid therapies.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potent topical corticosteroids for dermatological conditions like eczema, psoriasis, and dermatitis.
• Anti-inflammatory Drug Research: Used in preclinical and clinical research to develop new anti-inflammatory and immunosuppressive agents.
• Steroid Prodrug Development: Serves as a model compound for creating prodrugs with enhanced skin penetration or modified release profiles.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for HPLC, LC-MS, or NMR method development and validation.
• Biochemical Research: Used in studies investigating glucocorticoid receptor binding affinity, metabolism, and signal transduction pathways.

Basic Information

Item	Detail
Product Name	9-Fluoro-11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 21-Salicylate
CAS No.	68497-93-8
Molecular Formula	C28H31FO7
Molecular Weight	498.54 g/mol
Synonyms	Fluocortin Butyl; Fludroxycortide 21-Salicylate; 9α-Fluoro-11β,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-salicylate; 6α-Fluoro-16α-methylprednisolone 21-salicylate; Fluocortin-21-salicylate; Prednylidene 21-salicylate, 9-fluoro-11β,17-dihydroxy-; SH-770; Zyma-770
EINECS	Contact for details

Quality Control

Our 9-Fluoro-11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 21-Salicylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. We provide a Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency. Avoid prolonged exposure to high humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.