Description

9-Fluoro-11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 21-Acetylsalicylate is a high-purity, synthetic corticosteroid derivative, specifically the 21-acetylsalicylate ester of a fluorinated pregnadiene. This compound matters as a critical pharmaceutical intermediate and reference standard for the research and development of potent anti-inflammatory and immunosuppressive agents. It is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in steroid chemistry and advanced drug discovery programs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel, high-potency topical and systemic corticosteroid drugs.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing of steroid-based pharmaceuticals.
• Biochemical Research: A tool compound for studying glucocorticoid receptor (GR) binding affinity, metabolism, and structure-activity relationships (SAR).
• Veterinary Medicine Development: Potential intermediate for creating anti-inflammatory treatments for animal health applications.
• Metabolite Studies: Useful in research investigating the metabolic pathways and esterase-mediated hydrolysis of corticosteroid prodrugs.

Basic Information

Product Name	9-Fluoro-11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 21-Acetylsalicylate
CAS No.	68497-92-7
Molecular Formula	C30H35FO8
Molecular Weight	542.60 g/mol
Synonyms	Fluorometholone 21-Acetylsalicylate; 9α-Fluoro-11β,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-(2-acetoxybenzoate); Fluorometholone Acetylsalicylate; 9α-Fluoro-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-(2-acetoxybenzoate); 9-Fluoro-11β,17,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-acetylsalicylate; Fluorometholone 21-(o-Acetoxybenzoate); Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-, 21-(2-acetoxybenzoate)
EINECS	Contact for details

Quality Control

Our 9-Fluoro-11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 21-Acetylsalicylate is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets exacting standards for research and pharmaceutical use. Certificates of Analysis (COA) documenting purity, related substances, and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.