Description

Arotinolol is a potent, non-selective β-adrenergic receptor antagonist (β-blocker) with intrinsic sympathomimetic activity. This compound is of significant interest in pharmaceutical research and development for its cardiovascular applications. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents for hypertension and angina pectoris. Arotinolol CAS NO 68377-92-4 represents a key intermediate and active pharmaceutical ingredient (API) for advanced medicinal formulations.

Application

• Pharmaceutical API Synthesis: Serves as the core active ingredient in the formulation of β-blocker medications.
• Cardiovascular Research: Used as a reference standard and investigational compound in preclinical and clinical studies targeting hypertension and heart conditions.
• Analytical Standard: Employed in quality control laboratories for method development, validation, and assay calibration using HPLC, LC-MS, or other analytical techniques.
• Biochemical Studies: Utilized in pharmacological research to study β-adrenergic receptor binding and signal transduction pathways.
• Process Development: Acts as a critical intermediate for chemical process optimization and scale-up in API manufacturing.

Basic Information

Product Name	Arotinolol
CAS No.	68377-92-4
Molecular Formula	C15H21N3O3S2
Molecular Weight	371.48 g/mol
Synonyms	5-[2-[(3-tert-Butylamino-2-hydroxypropyl)thio]-4-thiazolyl]-2-thiophenecarboxamide; Almarl; Arotinolo; Arotinololum; RO 31-1118; SM-108
EINECS	Contact for details

Quality Control

Our Arotinolol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and support our products with detailed Certificates of Analysis (COA) that include results for assay, related substances, residual solvents, and other critical parameters. Our quality standards align with ICH guidelines and current Good Manufacturing Practice (cGMP) principles for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.