Description

Arotinolol Hcl CAS NO 68377-91-3 is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) belonging to the class of non-selective β-adrenergic blocking agents. This compound is critical for the research, development, and production of cardiovascular medications, particularly those targeting hypertension and angina. It is an essential raw material for pharmaceutical manufacturers, R&D laboratories, and academic institutions engaged in cardiovascular drug synthesis and pharmacological studies.

Application

• Pharmaceutical API Synthesis: Primary use as an active pharmaceutical ingredient in the manufacture of finished dosage forms for cardiovascular therapy.
• Hypertension Medication Production: Key intermediate in the formulation of β-blocker drugs used to treat high blood pressure.
• Angina Pectoris Treatment: Utilized in the development of medications that manage chest pain caused by reduced blood flow to the heart.
• Pharmacological Research: Serves as a reference standard and test compound in cardiovascular and autonomic nervous system research.
• Process Development & Scale-up: Used by process chemists for optimizing synthetic routes and scaling production from laboratory to commercial batch sizes.
• Analytical Standard: Employed as a high-purity standard for quality control testing, method validation, and regulatory submissions.

Basic Information

Product Name	Arotinolol Hydrochloride
CAS No.	68377-91-3
Molecular Formula	C15H24N2O3S•HCl
Molecular Weight	356.89 g/mol
Synonyms	Arotinolol Hydrochloride; Arotinolol HCl; 5-[2-[(3-tert-Butylamino-2-hydroxypropyl)thio]-4-thiazolyl]-2-thiophenecarboxamide Hydrochloride; Almarl (brand name); YM-09538; (RS)-Arotinolol Hydrochloride; (±)-Arotinolol Hydrochloride
EINECS	Contact for details

Quality Control

Our Arotinolol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, typical of pharmaceutical-grade materials. We provide full traceability and support regulatory compliance. Certificates of Analysis (COA) documenting results for assay, related substances, residual solvents, and other critical parameters are available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent absorption of atmospheric moisture, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.