Description

D-Pindolol is a high-purity, non-racemic stereoisomer of the β-adrenergic receptor antagonist Pindolol, specifically the (R)-enantiomer. This compound is of significant value in pharmaceutical research and development, serving as a critical chiral building block and reference standard for studying stereoselective drug action and metabolism. It is primarily utilized by researchers and manufacturers in the pharmaceutical and fine chemical sectors for developing enantiomerically pure active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control of Pindolol and related compounds.
• Chiral Intermediate: Serves as a key starting material or intermediate in the enantioselective synthesis of novel β-blockers and other therapeutic agents.
• Biochemical Research: Employed in pharmacological studies to investigate the specific binding affinity and activity of the (R)-enantiomer at β-adrenergic receptors.
• Metabolite Studies: Utilized in ADME (Absorption, Distribution, Metabolism, Excretion) research to understand the stereoselective metabolic pathways of β-blocking agents.
• Impurity Profiling: Acts as a critical impurity standard for monitoring the enantiomeric purity of racemic Pindolol APIs during manufacturing.

Basic Information

Product Name	D-Pindolol
CAS No.	68374-35-6
Molecular Formula	C₁₄H₂₀N₂O₂
Molecular Weight	248.32 g/mol
Synonyms	(R)-Pindolol; (R)-(+)-Pindolol; Dex-Pindolol; (R)-1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol; (2R)-1-(1H-Indol-4-yloxy)-3-(isopropylamino)propan-2-ol; Pindolol R-enantiomer; Levotensin (enantiomer); Viskin (enantiomer)
EINECS	Contact for details

Quality Control

Our D-Pindolol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess determination, to ensure high chemical and isomeric purity. We provide full traceability and Certificates of Analysis (COA) detailing identity, purity, and impurity profiles, supporting compliance with cGMP and ICH guidelines for research materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.