Description

(+)-n-Methyl-3-(5,10,11,11A-Tetrahydro-9-Hydroxy-11-Methoxy-8-Methyl-5-Oxo-1H-Pyrrolo[2,1-C][1,4]Benzodiazepine-2-Yl)Propenamide is a complex, chiral benzodiazepine derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical high-purity intermediate or reference standard for the synthesis and study of novel bioactive molecules targeting the central nervous system. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel benzodiazepine-based active pharmaceutical ingredients (APIs).
• Reference Standard: Used for analytical method development, validation, and quality control (HPLC, LC-MS) in pharmaceutical manufacturing.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity for neurological targets.
• Preclinical Development: Employed in the production of batches for pharmacological profiling, toxicology studies, and formulation development.
• Academic Research: Utilized in university and institutional labs for studying benzodiazepine pharmacology and synthesizing novel analogs.
• Process Chemistry: Acts as a starting material or intermediate for scaling up synthetic routes under GMP or non-GMP conditions.

Basic Information

Product Name	(+)-n-Methyl-3-(5,10,11,11A-Tetrahydro-9-Hydroxy-11-Methoxy-8-Methyl-5-Oxo-1H-Pyrrolo[2,1-C][1,4]Benzodiazepine-2-Yl)Propenamide
CAS No.	68373-95-5
Molecular Formula	C₂₁H₂₅N₃O₅
Molecular Weight	399.44 g/mol
Synonyms	(+)-N-Methyl-3-(5,10,11,11a-tetrahydro-9-hydroxy-11-methoxy-8-methyl-5-oxo-1H-pyrrolo[2,1-c][1,4]benzodiazepin-2-yl)propenamide; (S)-N-Methyl-3-(5,10,11,11a-tetrahydro-9-hydroxy-11-methoxy-8-methyl-5-oxo-1H-pyrrolo[2,1-c][1,4]benzodiazepin-2-yl)acrylamide; NSC 339586; Pyrrolobenzodiazepine Derivative; PBD Intermediate; (+)-DC-81 Analog; Antibody-Drug Conjugate (ADC) Linker Payload Intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We employ advanced analytical techniques including HPLC, chiral HPLC, LC-MS, and NMR for characterization. While typically supplied as a high-purity research grade, production can be aligned with ICH guidelines for stability and impurity profiling to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. For long-term storage, consider desiccant and inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.