Description

9Beta,11Beta-Epoxy-6Alpha-Fluoro-21-Hydroxy-16Alpha,17-(Isopropylidene)Dioxypregna-1,4-Diene-3,20-Dione is a high-purity synthetic steroid derivative and a key pharmaceutical intermediate. This compound matters for its role in the synthesis of advanced corticosteroid APIs, where its specific stereochemistry and functional groups are critical for biological activity. It is primarily needed by pharmaceutical R&D laboratories and manufacturers specializing in anti-inflammatory, immunosuppressive, and dermatological drug development.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of potent corticosteroid active pharmaceutical ingredients (APIs).
• Anti-inflammatory Drug Research: Used in the development and production of novel glucocorticoid receptor agonists.
• Immunosuppressant Synthesis: Serves as a precursor for compounds used to manage autoimmune disorders and prevent organ transplant rejection.
• Dermatological Preparations: Employed in the manufacture of topical creams and ointments for treating severe skin conditions like eczema and psoriasis.
• Steroid Chemistry Research: A valuable reference standard and starting material for academic and industrial research into steroid structure-activity relationships.
• Veterinary Pharmaceutical Development: Used in creating anti-inflammatory treatments for animals.

Basic Information

Product Name	9Beta,11Beta-Epoxy-6Alpha-Fluoro-21-Hydroxy-16Alpha,17-(Isopropylidene)Dioxypregna-1,4-Diene-3,20-Dione
CAS No.	68352-03-4
Molecular Formula	C24H29FO6
Molecular Weight	432.48 g/mol
Synonyms	9β,11β-Epoxy-6α-fluoro-21-hydroxy-16α,17-(isopropylidenedioxy)pregna-1,4-diene-3,20-dione; 6α-Fluoro-9β,11β-epoxy-21-hydroxy-16α,17-(isopropylidenedioxy)pregna-1,4-diene-3,20-dione; 6α-Fluoro-16α,17α-isopropylidenedioxy-9β,11β-epoxypregna-1,4-diene-3,20-dione-21-ol; 16α,17α-Isopropylidenedioxy-9β,11β-epoxy-6α-fluoropregna-1,4-diene-3,20-dione-21-ol; A key intermediate for Difluprednate; Contact for details on additional synonyms.
EINECS	Contact for details

Quality Control

Our 9Beta,11Beta-Epoxy-6Alpha-Fluoro-21-Hydroxy-16Alpha,17-(Isopropylidene)Dioxypregna-1,4-Diene-3,20-Dione is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing all critical quality attributes. Production can be aligned with cGMP guidelines for pharmaceutical intermediate applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.