Description

(-)-Acebutolol is the single enantiomer of the β-adrenergic blocking agent acebutolol, specifically the (S)-(-) form. This high-purity chiral intermediate is critical for pharmaceutical research and development, particularly in the synthesis of enantiomerically pure cardiovascular drugs. It is primarily utilized by pharmaceutical manufacturers and advanced research institutions focusing on cardioselective β-blockers and stereospecific drug development.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: Key chiral building block in the synthesis of the β-blocker acebutolol hydrochloride.
• Pharmacological Research: Used in studies to investigate the stereospecific activity, metabolism, and receptor binding profiles of β-adrenergic antagonists.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.
• Process Development: Employed in the development and optimization of asymmetric synthesis and chiral separation processes.
• Drug Discovery: A valuable scaffold for medicinal chemistry programs aimed at discovering new cardiovascular therapeutics with improved selectivity.

Basic Information

Product Name	(-)-Acebutolol
CAS No.	68107-82-4
Molecular Formula	C18H28N2O4
Molecular Weight	336.43 g/mol
Synonyms	(S)-(-)-Acebutolol; (S)-Acebutolol; L-Acebutolol; (-)-1-(2-Acetyl-4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)butanamide; Acebutolol Impurity C (S-enantiomer); Sectral (enantiomer); N-[3-Acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]butanamide (S-form)
EINECS	Contact for details

Quality Control

Our (-)-Acebutolol is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets stringent specifications for pharmaceutical R&D use. A Certificate of Analysis (COA) detailing identity, purity, and enantiomeric excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.