Description

R-Acebutolol is a high-purity enantiomer of the β-blocker Acebutolol, specifically the (R)-enantiomer. This compound is of significant value in pharmaceutical research and development, particularly for studying stereoselective activity and metabolism. It serves as a critical chiral intermediate or reference standard for analytical method development and pharmacological studies targeting cardiovascular conditions. Industries requiring this material include pharmaceutical R&D, analytical laboratories, and fine chemical synthesis.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for quality control and assay development of Acebutolol-based drug products.
• Chiral Intermediate: Serves as a key building block in the stereoselective synthesis of novel β-adrenergic blocking agents.
• Metabolic and Pharmacokinetic Studies: Employed in research to investigate the distinct biological activity, absorption, and distribution of the (R)-enantiomer.
• Analytical Method Development: Essential for developing and validating chiral separation methods using techniques like HPLC and CE.
• Impurity Profiling: Used to identify and quantify enantiomeric impurities in bulk S-Acebutolol or racemic Acebutolol.
• Academic and Clinical Research: Supports fundamental research into the mechanisms of β-blockers and their stereospecific effects.

Basic Information

Product Name	R-Acebutolol
CAS No.	68107-81-3
Molecular Formula	C18H28N2O4
Molecular Weight	336.43 g/mol
Synonyms	(R)-Acebutolol; (R)-N-[3-Acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]butanamide; (R)-1-(2-Acetyl-4-acetamidophenoxy)-2-hydroxy-3-isopropylaminopropane; Acebutolol R-Enantiomer; (R)-Acebutolol Hydrochloride (salt form); Dexacebutolol (less common); UNII-5M6K928A6P
EINECS	Contact for details

Quality Control

Our R-Acebutolol CAS NO 68107-81-3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assay, to ensure it meets stringent specifications for research and development use. A Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral excess, and related substances is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (R-enantiomer)
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.