Description

4-Hydroxytamoxifen is a potent and selective estrogen receptor modulator (SERM) and a key active metabolite of the pharmaceutical Tamoxifen. This compound is of critical importance in biochemical and pharmacological research, particularly in the study of estrogen receptor signaling pathways and breast cancer mechanisms. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and biotechnology companies for in vitro and in vivo studies, serving as a vital tool compound for developing and validating therapeutic strategies.

Application

• Biochemical Research: Used as a high-affinity ligand in estrogen receptor (ER) binding assays and studies of receptor conformation and function.
• Cell Biology Studies: Induces apoptosis and inhibits proliferation in estrogen receptor-positive (ER+) breast cancer cell lines for mechanistic research.
• Pharmaceutical Development: Serves as a reference standard and an active pharmaceutical ingredient (API) intermediate in the development of novel SERMs and anti-cancer therapies.
• Molecular Biology: A tool for modulating gene expression in studies of estrogen-responsive genes and pathways.
• Preclinical Research: Employed in animal models to investigate the efficacy, pharmacokinetics, and metabolism of tamoxifen and related compounds.

Basic Information

Product Name	4-Hydroxytamoxifen
CAS No.	68047-06-3
Molecular Formula	C26H29NO2
Molecular Weight	387.52 g/mol
Synonyms	Afimoxifene; (Z)-4-Hydroxytamoxifen; trans-4-Hydroxytamoxifen; ICI 79280; 1-[4-[2-(Dimethylamino)ethoxy]phenyl]-1-(4-hydroxyphenyl)-2-phenyl-1-butene; (Z)-1-(4-β-Dimethylaminoethoxyphenyl)-1-(4-hydroxyphenyl)-2-phenylbut-1-ene; 4-OHT; 4-OHTAM
EINECS	Contact for details

Quality Control

Our 4-Hydroxytamoxifen is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to ensure traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Isomeric Purity (Z-Isomer)	≥99.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.