Description

4-Fluoro-3-(Trifluoromethyl)Benzonitrile is a high-value fluorinated aromatic nitrile building block, essential for introducing specific steric and electronic properties into advanced molecular architectures. Its unique structure, featuring both fluorine and a trifluoromethyl group, makes it a critical intermediate for synthesizing compounds with enhanced metabolic stability, lipophilicity, and binding affinity. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the fluorine motifs improve biological activity and environmental profile.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for high-performance displays.
• Organic Electronics: Employed in the development of novel organic semiconductors and electron-transport materials.
• Advanced Polymer Chemistry: Acts as a monomer or modifier to create specialty polymers with unique chemical resistance and thermal properties.
• Chemical Research & Development: A versatile reagent for exploring new reactions and creating complex fluorinated compounds in academic and industrial R&D settings.

Basic Information

Product Name	4-Fluoro-3-(Trifluoromethyl)Benzonitrile
CAS No.	67515-59-7
Molecular Formula	C8H3F4N
Molecular Weight	189.11 g/mol
Synonyms	4-Fluoro-3-(trifluoromethyl)benzonitrile; 3-Trifluoromethyl-4-fluorobenzonitrile; 4-Fluoro-alpha,alpha,α-trifluoro-m-toluonitrile; 2-Fluoro-5-cyanobenzotrifluoride; 5-Cyano-2-fluorobenzotrifluoride; Benzonitrile, 4-fluoro-3-(trifluoromethyl)-; 67515-59-7
EINECS	Contact for details

Quality Control

Every batch of 4-Fluoro-3-(Trifluoromethyl)Benzonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments. Our standard grade typically meets a purity specification of ≥97% (by HPLC), with custom purification available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.