Description

Alclometasone is a synthetic corticosteroid with potent anti-inflammatory and antipruritic properties, widely recognized for its efficacy in topical formulations. This compound is a critical active pharmaceutical ingredient (API) for the development of dermatological treatments, offering a favorable therapeutic index. It is primarily utilized by pharmaceutical manufacturers and R&D institutions in the production of creams, ointments, and lotions for managing various skin conditions.

Application

• Topical Corticosteroid Formulations: Primary API in prescription-strength creams, ointments, and lotions for treating inflammatory skin disorders.
• Dermatological R&D: Key intermediate in research for developing new topical anti-inflammatory and anti-eczema medications.
• Veterinary Pharmaceuticals: Used in topical preparations for managing dermatological conditions in animals.
• Compounding Pharmacy: Sourced by specialized pharmacies for preparing customized topical medication blends.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical labs.

Basic Information

Product Name	Alclometasone
CAS No.	67452-97-5
Molecular Formula	C22H28ClFO5
Molecular Weight	426.91 g/mol
Synonyms	Alclometasone Dipropionate; 7α-Chloro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate; SQ-15101; Delonal; Aclovate; (11β,16α)-7-Chloro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate
EINECS	Contact for details

Quality Control

Our Alclometasone is manufactured under strict quality management systems, ensuring it meets the stringent requirements for pharmaceutical intermediates. Each batch is tested against comprehensive specifications, including identity, purity, and impurity profiles. A Certificate of Analysis (COA) detailing results from tests such as HPLC assay, related substances, and residual solvents is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.