Description

Cyclomethasone CAS NO 67372-50-3 is a synthetic corticosteroid belonging to the glucocorticoid class, valued for its potent anti-inflammatory and immunosuppressive properties. This compound is a critical intermediate in the pharmaceutical synthesis of more complex steroid-based active pharmaceutical ingredients (APIs). It is primarily required by manufacturers in the pharmaceutical and fine chemical industries for the development and production of topical and systemic corticosteroid medications.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of potent topical corticosteroids for dermatological conditions like eczema, psoriasis, and dermatitis.
• API Synthesis: Used in the research and commercial production of various glucocorticoid receptor agonist active pharmaceutical ingredients.
• Veterinary Medicine: Employed in the formulation of anti-inflammatory and anti-pruritic treatments for animals.
• Biochemical Research: Serves as a reference standard and tool compound in pharmacological studies investigating steroid hormone pathways and receptor interactions.
• Fine Chemical Production: Utilized as a specialized intermediate for custom synthesis and contract manufacturing of steroid derivatives.

Basic Information

Product Name	Cyclomethasone
CAS No.	67372-50-3
Molecular Formula	C24H31FO5
Molecular Weight	418.50 g/mol
Synonyms	9-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione; 9α-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione; 9α-Fluoro-16α-methylprednisolone; Cyclomethasone; Fluprednisolone 16α-methyl ether; NSC 113927
EINECS	Contact for details

Quality Control

Our Cyclomethasone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) detailing specifications such as assay, related substances, and residual solvents, aligning with ICH guidelines. Custom synthesis and development of specific pharmacopeial grades (e.g., USP) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to protect from moisture. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.