Description

7-[[(1H-Pyrrol-2-Yl)Methyl]Amino]Actinomycin D is a structurally modified derivative of the potent antitumor antibiotic Actinomycin D, designed to explore enhanced therapeutic profiles and altered biological activity. This compound is of significant interest in advanced pharmaceutical research for its potential to modulate DNA-binding affinity and cytotoxicity. It serves as a critical intermediate and research tool for oncology and molecular biology laboratories focused on developing next-generation chemotherapeutic agents and studying transcription inhibition mechanisms.

Application

• Pharmaceutical Research & Development: As a key intermediate in the synthesis of novel actinomycin-based anticancer drug candidates.
• Oncology Studies: Used in biochemical and cellular assays to investigate mechanisms of DNA intercalation and transcription inhibition.
• Molecular Biology: Employed as a research tool to study the effects on RNA polymerase activity and gene expression.
• Structure-Activity Relationship (SAR) Studies: Critical for medicinal chemistry programs aiming to understand and improve the efficacy and selectivity of actinomycin analogs.
• Biochemical Reagent: Used in specialized laboratory settings for probing nucleic acid-protein interactions.

Basic Information

Product Name	7-[[(1H-Pyrrol-2-Yl)Methyl]Amino]Actinomycin D
CAS No.	67230-67-5
Molecular Formula	C₆₃H₈₆N₁₂O₁₆
Molecular Weight	1307.45 g/mol
Synonyms	7-[(1H-Pyrrol-2-ylmethyl)amino]actinomycin D; 7-(Pyrrol-2-ylmethylamino)actinomycin D; Actinomycin D, 7-[[(1H-pyrrol-2-yl)methyl]amino]-; 7-Aminoactinomycin D pyrrolylmethyl derivative; NSC 673529; LMB-050; (7S)-7-[[(1H-Pyrrol-2-yl)methyl]amino]actinomycin D
EINECS	Contact for details

Quality Control

Our 7-[[(1H-Pyrrol-2-Yl)Methyl]Amino]Actinomycin D is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay results, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and light-sensitive; it must be handled under inert atmosphere and kept in a desiccated environment to maintain stability and potency.

Specification

Item	Specification
Appearance	Orange to red solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.