Description

Alclometasone Dipropionate is a synthetic corticosteroid ester prodrug, widely recognized for its potent anti-inflammatory and antipruritic properties. This high-purity active pharmaceutical ingredient (API) is essential for formulating safe and effective topical dermatological treatments. It is primarily required by pharmaceutical manufacturers and compounding pharmacies for the production of creams, ointments, and lotions to manage various skin conditions.

Application

• Topical Corticosteroid Formulations: Primary API in prescription-strength creams, ointments, and lotions for treating inflammatory skin disorders.
• Dermatological Preparations: Used in medications for eczema, psoriasis, allergic dermatitis, and other corticosteroid-responsive dermatoses.
• Anti-Pruritic Agents: Key component in formulations designed to relieve severe itching associated with various skin conditions.
• Veterinary Pharmaceuticals: Incorporated into topical treatments for inflammatory skin conditions in animals.
• Compounding Pharmacy: Serves as a critical raw material for pharmacists creating customized topical medication strengths and combinations.
• Research & Development: Used in pharmaceutical R&D for developing new topical drug delivery systems and studying corticosteroid pharmacology.

Basic Information

Product Name	Alclometasone Dipropionate
CAS No.	66734-13-2
Molecular Formula	C28H37ClO7
Molecular Weight	521.04 g/mol
Synonyms	Alclometasone Dipropionate; 7α-Chloro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate; Alcovate; SCH 22219; Aclometasone Dipropionate; 7α-Chloro-16α-methyl-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-dipropionate
EINECS	266-451-6

Quality Control

Our Alclometasone Dipropionate is manufactured under strict quality systems and undergoes rigorous analytical testing to ensure it meets the highest standards for pharmaceutical use. Each batch is tested against relevant pharmacopeial specifications (such as USP/EP) for identity, purity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) documenting all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. The container should be kept tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	NMT 1.0%
Related Substances (HPLC)	Total impurities: NMT 2.0% Any individual impurity: NMT 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	NMT 20 ppm
Sulfated Ash	NMT 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.