Description

S-(-)-Befunolol is the pharmacologically active enantiomer of the β-adrenergic receptor antagonist befunolol. This high-purity chiral building block is critical for research and development in advanced pharmaceutical synthesis. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and fine chemical industries for creating enantiomerically pure active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of enantiomerically pure β-blocker APIs.
• Biochemical Research: Used as a reference standard and tool compound in pharmacological studies of β-adrenergic receptors.
• Asymmetric Synthesis: Serves as a valuable chiral synthon or resolving agent in stereoselective chemical transformations.
• Analytical Standard: Provides a high-purity standard for method development and quality control in HPLC and chiral analysis.
• Process Chemistry: Employed in route scouting and optimization for the commercial manufacture of chiral drugs.

Basic Information

Product Name	S-(-)-Befunolol
CAS No.	66685-76-5
Molecular Formula	C18H21NO4
Molecular Weight	315.36 g/mol
Synonyms	(S)-(-)-Befunolol; (S)-Befunolol; (-)-Befunolol; Befunolol S-(-)-enantiomer; 1-[7-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]-2-benzofuranyl]ethanone (S)-form; (S)-1-[7-[2-Hydroxy-3-(isopropylamino)propoxy]-2-benzofuranyl]ethanone; S-Befunolol
EINECS	Contact for details

Quality Control

Our S-(-)-Befunolol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets exacting standards for research and development use. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.