Description

(R)-(+)-Befunolol is a high-purity enantiomer of the β-adrenergic receptor antagonist, befunolol. This compound is of significant value in pharmaceutical research and development, particularly for studying stereoselective drug-receptor interactions and metabolic pathways. It is primarily required by pharmaceutical companies and advanced research institutions engaged in the synthesis of chiral active pharmaceutical ingredients (APIs) and the development of novel cardiovascular therapeutics.

Application

• Key chiral intermediate in the synthesis of enantiomerically pure β-blocker APIs.
• Pharmacological reference standard for stereoselective activity and toxicity studies.
• Building block for research into novel cardiovascular and ophthalmic drug candidates.
• Substrate for metabolic and pharmacokinetic studies investigating chiral inversion.
• Critical material for analytical method development and validation (e.g., chiral HPLC).
• Use in academic and industrial research exploring structure-activity relationships (SAR) of adrenergic ligands.

Basic Information

Product Name	(R)-(+)-Befunolol
CAS No.	66685-75-4
Molecular Formula	C16H22NO3
Molecular Weight	276.35 g/mol
Synonyms	(R)-(+)-1-[7-[2-Hydroxy-3-(isopropylamino)propoxy]-2-benzofuranyl]ethanone; (R)-Befunolol; (+)-Befunolol; (R)-Bentos; (R)-Bentox; Befunolol R enantiomer; (R)-1-[7-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]-2-benzofuranyl]ethanone
EINECS	Contact for details

Quality Control

Our (R)-(+)-Befunolol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets exacting research-grade specifications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.5%
Chiral Purity (Chiral HPLC)	≥ 99.0% (R)-enantiomer
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.