Description

1,4-Difluoro-2-Methoxy-5-Nitrobenzene is a versatile fluorinated aromatic building block, prized for its unique substitution pattern that enables selective chemical transformations. Its core value lies in providing a reactive scaffold for synthesizing complex molecules in advanced research and development. This compound is essential for pharmaceutical chemists and agrochemical researchers developing novel active ingredients, particularly where the introduction of fluorine atoms and nitro/methoxy groups is strategically required.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for molecules containing fluorinated aromatic rings.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, pesticides, and fungicides where fluorine substitution enhances biological activity and stability.
• Material Science Research: Serves as a monomer or building block for creating specialized polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Chemistry: Acts as an intermediate in the production of complex, high-performance dyes and organic pigments.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to the presence of halogen atoms.
• Organic Synthesis & Process Development: Utilized in academic and industrial R&D for method development and as a standard reagent for introducing specific functional groups.

Basic Information

Product Name	1,4-Difluoro-2-Methoxy-5-Nitrobenzene
CAS No.	66684-63-7
Molecular Formula	C7H5F2NO3
Molecular Weight	189.12 g/mol
Synonyms	2,5-Difluoro-4-methoxynitrobenzene; 4-Methoxy-2,5-difluoronitrobenzene; 1,4-Difluoro-2-methoxy-5-nitro-benzene; 5-Nitro-1,4-difluoro-2-methoxybenzene; Benzene, 1,4-difluoro-2-methoxy-5-nitro-; 2-Methoxy-1,4-difluoro-5-nitrobenzene
EINECS	Contact for details

Quality Control

Our 1,4-Difluoro-2-Methoxy-5-Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.