Description

1,5-Difluoro-3-Methoxy-2-Nitro-Benzene is a high-purity, multi-functional aromatic building block of significant importance in advanced organic synthesis. Its unique substitution pattern, featuring fluorine and nitro groups, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a difluorinated aromatic core.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or building block for developing specialty polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Intermediate: Employed in the synthesis of complex organic dyes and pigments, leveraging the nitro group for further functionalization.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to create biaryl structures.
• Nucleophilic Aromatic Substitution: The activated nitro and fluoro groups make it reactive in SNAr reactions, allowing for the introduction of various nucleophiles.

Basic Information

Product Name	1,5-Difluoro-3-Methoxy-2-Nitro-Benzene
CAS No.	66684-61-5
Molecular Formula	C7H5F2NO3
Molecular Weight	189.12 g/mol
Synonyms	2-Nitro-1,5-difluoro-3-methoxybenzene; 3-Methoxy-2,6-difluoronitrobenzene; 1,5-Difluoro-3-methoxy-2-nitrobenzene; Benzene, 1,5-difluoro-3-methoxy-2-nitro-; 2,6-Difluoro-3-methoxynitrobenzene
EINECS	Contact for details

Quality Control

Our 1,5-Difluoro-3-Methoxy-2-Nitro-Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) detailing specifications such as assay (by HPLC), impurity profile, and physical characteristics. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to the presence of nitro and fluoro groups, it should be stored separately from strong reducing agents, strong bases, and incompatible materials.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.