Description

1,2,5-Trifluoro-3-nitrobenzene is a versatile fluorinated aromatic nitro compound, serving as a critical building block in advanced organic synthesis. Its unique trifluoro-nitro substitution pattern makes it a valuable precursor for the development of pharmaceuticals, agrochemicals, and specialty materials. This high-purity intermediate is essential for researchers and manufacturers in fine chemical, pharmaceutical, and agrochemical industries seeking to introduce fluorine atoms and nitro functionality into complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic cores to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the trifluoromethyl and nitro groups contribute to biological activity and selectivity.
• Liquid Crystal & Electronic Materials: Serves as a precursor for fluorinated liquid crystals and organic electronic materials, leveraging its electron-withdrawing properties.
• Dye & Pigment Manufacturing: Employed in the synthesis of specialized dyes and pigments where fluorine substitution enhances lightfastness and chemical resistance.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to create complex biaryl structures.
• Nucleophilic Aromatic Substitution: The nitro and fluorine groups activate the benzene ring for selective substitution reactions, enabling precise functionalization.
• Research & Development: A valuable reagent for academic and industrial R&D in medicinal chemistry and material science.
• Fluorine Chemistry Exploration: Used as a model compound to study the effects of multiple fluorine atoms on aromatic reactivity and physical properties.

Basic Information

Item	Information
Product Name	1,2,5-Trifluoro-3-nitrobenzene
CAS No.	66684-57-9
Molecular Formula	C6H2F3NO2
Molecular Weight	177.08 g/mol
Synonyms	3-Nitro-1,2,5-trifluorobenzene; 1,2,5-Trifluoro-3-nitro-benzene; Benzene, 1,2,5-trifluoro-3-nitro-; 2,4,5-Trifluoronitrobenzene; NSC 406925; 3-Nitro-1,2,5-trifluorobenzol
EINECS	Contact for details

Quality Control

Our 1,2,5-Trifluoro-3-nitrobenzene is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques including GC, HPLC, NMR, and MS for comprehensive characterization. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment. Our quality system is designed to meet the stringent requirements of cGMP and ISO standards for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, open flames, and incompatible materials such as strong reducing agents and bases. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0% (Area %)
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.