Description

Aclacinomycin is an anthracycline antibiotic and antineoplastic agent derived from *Streptomyces galilaeus*. This compound is valued for its potent antitumor activity, primarily functioning as a topoisomerase inhibitor and intercalating agent to disrupt DNA replication in cancer cells. It is a critical intermediate and reference standard in pharmaceutical research and development, particularly for oncology studies. Key industries requiring this high-purity compound include pharmaceutical R&D, biotechnology, and academic research institutions focused on cancer therapeutics.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel chemotherapeutic agents.
• Oncology Studies: Used in in vitro and in vivo research to study mechanisms of action, efficacy, and resistance profiles of anthracycline-based cancer therapies.
• Biochemical Research: Employed as a tool compound to investigate DNA intercalation, topoisomerase I and II inhibition, and apoptosis induction pathways.
• Quality Control & Analytical Testing: Essential as a certified reference material (CRM) for HPLC, LC-MS, and other analytical methods to ensure the purity and identity of pharmaceutical batches.
• Academic Research: Utilized in university and institutional labs for fundamental studies in medicinal chemistry, pharmacology, and molecular biology related to anticancer drugs.

Basic Information

Product Name	Aclacinomycin
CAS No.	66676-88-8
Molecular Formula	C₄₂H₅₃NO₁₅
Molecular Weight	811.87 g/mol
Synonyms	Aclacinomycin A; Aclarubicin; Aclacinon; Aclaplastin; ACM-A; NSC 208734; Antibiotic MA 144 A1; (1R,2R,4S)-4-[(2R,4S,5S,6S)-4-(Dimethylamino)-5-[(2S,3S,4S,6R)-3-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-1-naphthacenecarboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Aclacinomycin is manufactured under strict quality management systems to ensure the highest standards of purity and consistency, suitable for research and development applications. Each batch is subjected to comprehensive analytical testing, including HPLC for purity determination, IR and NMR for structural confirmation, and stringent controls for residual solvents and impurities. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to guarantee traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C (in a refrigerator) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccant and under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange-yellow powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.