Description

2-(2-Fluorophenyl)-4,5-Dihydro-4,4-Dimethyloxazole is a specialized heterocyclic building block featuring a fluorinated aromatic ring fused to a dimethyl-substituted oxazoline ring. This compound is valued for its unique molecular scaffold, which serves as a versatile intermediate in advanced organic synthesis, particularly for introducing fluorinated motifs into target molecules. It is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, potentially for central nervous system (CNS) agents, anti-inflammatory, or antimicrobial applications.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, or insecticides where the fluorine atom enhances biological activity and environmental stability.
• Ligand and Catalyst Development: The oxazoline moiety can act as a chiral ligand in asymmetric catalysis, useful for creating enantiomerically pure compounds.
• Material Science Research: Serves as a building block for advanced polymers or liquid crystals where fluorination modifies physical properties like solubility and thermal stability.
• Fluorine Chemistry Research: An essential substrate for methodological studies in fluorination reactions and the exploration of new fluorinated heterocycles.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke molecules for client projects.

Basic Information

Product Name	2-(2-Fluorophenyl)-4,5-Dihydro-4,4-Dimethyloxazole
CAS No.	66464-20-8
Molecular Formula	C11H12FNO
Molecular Weight	193.22 g/mol
Synonyms	4,4-Dimethyl-2-(2-fluorophenyl)-4,5-dihydrooxazole; 2-(2-Fluorophenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole; 2-(2-Fluorophenyl)-4,4-dimethyl-2-oxazoline; 2-(o-Fluorophenyl)-4,4-dimethyl-4,5-dihydrooxazole; 4,4-Dimethyl-2-(o-fluorophenyl)-2-oxazoline; 66464-20-8; Oxazole, 4,5-dihydro-4,4-dimethyl-2-(2-fluorophenyl)-
EINECS	Contact for details

Quality Control

Every batch of 2-(2-Fluorophenyl)-4,5-Dihydro-4,4-Dimethyloxazole is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and process development. A detailed Certificate of Analysis (COA) specifying identity, purity, and impurity profiles by techniques such as HPLC, GC, NMR, and IR spectroscopy is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong alkalis and fluorides. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.