Description

Saframycin B CAS NO 66082-28-8 is a potent quinone-containing antibiotic and antitumor agent belonging to the saframycin family. This compound is valued for its significant biological activity, particularly its ability to inhibit DNA synthesis and function, making it a crucial tool in biochemical research and a lead compound in drug discovery. It is primarily utilized by researchers in pharmaceutical development, oncology research, and microbiology for investigating novel therapeutic pathways and mechanisms of action.

Application

• Anticancer Research: Serves as a key reference standard and active pharmaceutical ingredient (API) in preclinical studies for evaluating antitumor efficacy and mechanisms.
• Antibiotic Mechanism Studies: Used in microbiological research to study its potent antibacterial activity, particularly against Gram-positive bacteria.
• Biochemical Tool Compound: Employed in laboratories to investigate DNA interaction, alkylation processes, and apoptosis induction in cell lines.
• Pharmaceutical Development: Acts as a lead compound for the synthesis and development of novel chemotherapeutic agents and antibiotic derivatives.
• Academic Research: Utilized in university and institutional labs for fundamental studies on natural product chemistry and bioactivity.

Basic Information

Product Name	Saframycin B
CAS No.	66082-28-8
Molecular Formula	C₂₈H₃₃N₃O₇
Molecular Weight	523.58 g/mol
Synonyms	Saframycin B; Antibiotic A-130; NSC 339638; (3S,4aS,13aS,14R)-14-[(2R)-1-Hydroxybutan-2-yl]-3,4,4a,5,13,13a,14,15-octahydro-1H,7H-pyrido[1',2':1,2]pyrazino[3,4-b]indole-7,10,12(2H,8H)-trione; A 130; Antibiotic A 130
EINECS	Contact for details

Quality Control

Our Saframycin B is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research purposes. Each lot undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods and purity assessment by HPLC. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Keep the container in a dry, cool, and well-ventilated area. For long-term storage, consider storing under inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	Reddish-brown to dark brown powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.