Description

Saframycin A is a potent, naturally occurring quinone antibiotic isolated from microbial fermentation. This compound is valued for its significant biological activity, particularly as a cytotoxic agent and DNA binder, making it a crucial reference standard and research tool. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in oncology research and novel drug discovery programs.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel anti-cancer therapeutics.
• Biochemical Research: Used as a potent tool compound in molecular biology to study DNA interaction mechanisms, apoptosis, and cell cycle inhibition.
• Antibiotic Studies: Employed in microbiological research to investigate its mechanism of action against Gram-positive bacteria and its structure-activity relationships (SAR).
• Academic & Institutional Laboratories: Utilized for teaching and advanced research in medicinal chemistry, pharmacology, and natural product chemistry.
• Pre-clinical Development: Acts as a lead compound or a benchmark for evaluating the efficacy of new synthetic analogs in pre-clinical models.

Basic Information

Product Name	Saframycin A
CAS No.	66082-27-7
Molecular Formula	C29H31N3O7
Molecular Weight	533.58 g/mol
Synonyms	Saframycin A; Antibiotic LL-BM547β; NSC 339638; (3S,4aS,13aS)-3-Ethyl-1,2,3,4,4a,5,12,13,13a,14-decahydro-4a,7,14-trihydroxy-4a,8,13a-trimethyl-9,12-dioxo-3,10-methano-1H-pyrazino[1',2':1,5]pyrrolo[2,3-g]isoquinoline-11-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Saframycin A is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods and purity determination by HPLC. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the material may be stored at 2-8°C. The compound is light-sensitive and should be handled under appropriate conditions to prevent degradation. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.